Like the Floor Guardians who manage the defense of the whole floor, Area Guardians guard a certain area appointed to them. As they are large in number and most of them are not very strong, the word "Guardian" usually refers to the Floor Guardians only.
The Undead King Arc
- Main article: The Undead King Arc
Ainz Ooal Gown ordered the Floor Guardians to report to the Area Guardians about the changes in the Great Tomb of Nazarick.
The Bloody Valkyrie Arc
- Main article: The Bloody Valkyrie Arc
During the unprecedented event of Shalltear Bloodfallen's brainwashing by an unknown foe using a World Item, forced Ainz to recall majority of Nazarick's forces. To protect the Floor Guardians from being compromised, he went to the Area Guardian of the Treasury, Pandora's Actor, to retrieve the stored World Items to equip his children.
The Men in the Kingdom Arc
- Main article: The Men in the Kingdom Arc
The Invaders of the Large Tomb Arc
- Main article: The Invaders of the Large Tomb Arc
Kyouhukou of the Area Guardians assisted in testing the Great Tomb of Nazarick's defense systems during an invasion by several teams of workers. In his part he eliminated the worker group Heavy Masher.
The Ruler of Conspiracy Arc
- Main article: The Ruler of Conspiracy Arc
Though most of the Area Guardians are weaker than the Floor Guardians, there are some strong NPCs among them. There are Area Guardians that are optimized for battle are considered to be stronger than some of the weaker Floor Guardians like Demiurge.
- Some Area Guardians are in charge of guarding the most vital area in Nazarick. Pandora's Actor guards the vault of the World Items in the Treasury and Aureole Omega guards the Guild Weapon in the Cherry Blossom Sanctuary.